About Zinc finger and SCAN domain-containing protein 4
Zinc finger and SCAN domain-containing protein 4 (ZSCAN4) is a protein
from Homo sapiens identified by UniProt accession
Q8NAM6, 433 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Zinc finger and SCAN domain-containing protein 4 |
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| UniProt accession | Q8NAM6 |
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| Gene | ZSCAN4 |
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| Organism | Homo sapiens |
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| Length | 433 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- neoplasm · score 0.06
- head and neck squamous cell carcinoma · score 0.06
- cancer · score 0.05
- ulcerative colitis · score 0.03
- Facioscapulohumeral dystrophy · score 0.02
- facioscapulohumeral muscular dystrophy · score 0.02
- non-small cell lung carcinoma · score 0.01
- Atypical Lipomatous Tumor · score 0.01
- urothelial carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NAM6-F1 | alphafold | PREDICTED | 50.04 | — |
Amino-acid sequence (433 residues)
MALDLRTIFQ CEPSENNLGS ENSAFQQSQG PAVQREEGIS EFSRMVLNSF QDSNNSYARQ ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND KASVKEKWKS SGKNLERFIE DLTDDSINPP ALVHVHMQGQ EALFSEDMPL RDVIVHLTKQ VNAQTTREAN MGTPSQTSQD TSLETGQGYE DEQDGWNSSS KTTRVNENIT NQGNQIVSLI IIQEENGPRP EEGGVSSDNP YNSKRAELVT ARSQEGSING ITFQGVPMVM GAGCISQPEQ SSPESALTHQ SNEGNSTCEV HQKGSHGVQK SYKCEECPKV FKYLCHLLAH QRRHRNERPF VCPECQKGFF QISDLRVHQI IHTGKKPFTC SMCKKSFSHK TNLRSHERIH TGEKPYTCPF CKTSYRQSST YHRHMRTHEK ITLPSVPSTP EAS
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