Mitoguardin 1 (MIGA1)

About Mitoguardin 1

Mitoguardin 1 (MIGA1) is a protein from Homo sapiens identified by UniProt accession Q8NAN2, 632 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	Mitoguardin 1
UniProt accession	Q8NAN2
Gene	MIGA1
Organism	Homo sapiens
Length	632 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

calcium measurement · score 0.37
smoking initiation · score 0.29
body height · score 0.17
vital capacity · score 0.15
body mass index · score 0.12
physical activity measurement · score 0.12
reticulocyte count · score 0.10
birth weight · score 0.10
platelet count · score 0.10
electrocardiography · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NAN2-F1	alphafold	PREDICTED	64.06	—

Amino-acid sequence (632 residues)

MSDCCSAPGI SWEAGVGRPA VPGLELQIRR GAMSEETVSE SQFSLKTAAL RVFDLPLTWY YSLSQIKFSP VAKKLFVVTA VSAISVIFLA HHFKRKRGKK KGKILPWEPE HLILEYTKRA ASDKGSSCSS SRQNLTLSLS STKDKGSQVC NYANGGLFSK YSGSAQSLAS VQSVNSCHSC ACGNSNSWDK ADEDDIKLVN IPVTTPENLY LMGMELFEEA LRRWEQALTF RNRQAEDEAC GSIKLGAGDA IAEENVDDII STEFIHKLEA LLQRAYRLQE EFEATLGASD PNSLADDIDK DTDITMKGNV EDFGLRDTLS IASTDSFASA AELAEHREVR HTYSLESLCH CPFYEEAMHL VEEGKIYSRV LRTEMLECLG DSDFLAKLHC IRQAFQVILS ESANRIFLAE SGRKILSALI VKARKNPKKF EDVFDEMIYF LEQTDHWGST EMELAARGVK NLNFYDVVLD FILMDSFEDL ENPPTSIQNV VNNRWLNSSF KETAVASSCW SVLKQKRQQM KIPDGFFAHF YAICEHISPV LAWGFLGPRN SLYDLCCFFK NQVLLFLKDI FDFEKVRYSS TETLAEDLMQ LLIRRTELLM AYLEADALRH TSSCLSSHGH VMSTGLLEAK VQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards