Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (P

About Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) is a protein from Homo sapiens identified by UniProt accession Q8NAT1, 580 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
UniProt accession	Q8NAT1
Gene	POMGNT2
Organism	Homo sapiens
Length	580 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NAT1-F1	alphafold	PREDICTED	92.35	—

Amino-acid sequence (580 residues)

MHLSAVFNAL LVSVLAAVLW KHVRLREHAA TLEEELALSR QATEPAPALR IDYPKALQIL MEGGTHMVCT GRTHTDRICR FKWLCYSNEA EEFIFFHGNT SVMLPNLGSR RFQPALLDLS TVEDHNTQYF NFVELPAAAL RFMPKPVFVP DVALIANRFN PDNLMHVFHD DLLPLFYTLR QFPGLAHEAR LFFMEGWGEG AHFDLYKLLS PKQPLLRAQL KTLGRLLCFS HAFVGLSKIT TWYQYGFVQP QGPKANILVS GNEIRQFARF MTEKLNVSHT GVPLGEEYIL VFSRTQNRLI LNEAELLLAL AQEFQMKTVT VSLEDHTFAD VVRLVSNASM LVSMHGAQLV TTLFLPRGAT VVELFPYAVN PDHYTPYKTL AMLPGMDLQY VAWRNMMPEN TVTHPERPWD QGGITHLDRA EQARILQSRE VPRHLCCRNP EWLFRIYQDT KVDIPSLIQT IRRVVKGRPG PRKQKWTVGL YPGKVREARC QASVHGASEA RLTVSWQIPW NLKYLKVREV KYEVWLQEQG ENTYVPYILA LQNHTFTENI KPFTTYLVWV RCIFNKILLG PFADVLVCNT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2)