Uncharacterized protein C8orf58 (C8orf58)

About Uncharacterized protein C8orf58

Uncharacterized protein C8orf58 (C8orf58) is a protein from Homo sapiens identified by UniProt accession Q8NAV2, 365 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Uncharacterized protein C8orf58
UniProt accession	Q8NAV2
Gene	C8orf58
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

C-reactive protein measurement · score 0.18
triglyceride measurement · score 0.17
serum non-albumin protein measurement · score 0.16
total blood protein measurement · score 0.15
creatinine measurement · score 0.15
Parkinson disease · score 0.15
type 2 diabetes mellitus · score 0.14
glomerular filtration rate · score 0.13
Abnormality of refraction · score 0.13
cystatin C measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NAV2-F1	alphafold	PREDICTED	54.18	—

Amino-acid sequence (365 residues)

MMGRRRAFAV DGRDGAGEGL ARGCIVPGVT STYRRIPDAA HGCSSWERGD KFRGVGREAL FLKLASRDSG VEMAVGDSPL AALPGLSQDS LDFESSGSSE PPAQVGRLLA SQKLGEVLER SRRLPTAPTS LSGQHRSLRL ASKPEREVPL GAGQQESMEA DTDLEAGLEE EAVGGLGPGA WACLPGQGLR YLEHLCLVLE QMARLQQLYL QLRIQRPPGD PGEEESTRAP LPSPLHTPGN RGQGPWELLS QTEHTGAKAA SPPKVEVPSA NPPRLPETPV EPTYHLPSSQ GHKRDISHWD KVKVLLNRIC RRSHHHPEPP APPDGSDPRI ESRDLPERPQ CRPHRKTFMP SLVVKKQRAK NLSVG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards