Keratinocyte differentiation factor 1 (KDF1)

About Keratinocyte differentiation factor 1

Keratinocyte differentiation factor 1 (KDF1) is a protein from Homo sapiens identified by UniProt accession Q8NAX2, 398 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Keratinocyte differentiation factor 1
UniProt accession	Q8NAX2
Gene	KDF1
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

autosomal dominant hypohidrotic ectodermal dysplasia · score 0.45
tooth agenesis · score 0.29
sex hormone-binding globulin measurement · score 0.26
myeloid white cell count · score 0.25
vitamin D measurement · score 0.20
testosterone measurement · score 0.19
genetic disorder · score 0.19
reticulocyte count · score 0.17
heel bone mineral density · score 0.16
neutrophil count · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NAX2-F1	alphafold	PREDICTED	58.86	—

Amino-acid sequence (398 residues)

MPRPGHPRPA SGPPRLGPWE RPTELCLETY DKPPQPPPSR RTRRPDPKDP GHHGPESITF ISGSAEPALE SPTCCLLWRP WVWEWCRAAF CFRRCRDCLQ RCGACVRGCS PCLSTEDSTE GTAEANWAKE HNGVPPSPDR APPSRRDGQR LKSTMGSSFS YPDVKLKGIP VYPYPRATSP APDADSCCKE PLADPPPMRH SLPSTFASSP RGSEEYYSFH ESDLDLPEMG SGSMSSREID VLIFKKLTEL FSVHQIDELA KCTSDTVFLE KTSKISDLIS SITQDYHLDE QDAEGRLVRG IIRISTRKSR ARPQTSEGRS TRAAAPTAAA PDSGHETMVG SGLSQDELTV QISQETTADA IARKLRPYGA PGYPASHDSS FQGTDTDSSG APLLQVYC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards