Histone-lysine N-methyltransferase SMYD1 (SMYD1)

About Histone-lysine N-methyltransferase SMYD1

Histone-lysine N-methyltransferase SMYD1 (SMYD1) is a protein from Homo sapiens identified by UniProt accession Q8NB12, 490 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Histone-lysine N-methyltransferase SMYD1
UniProt accession	Q8NB12
Gene	SMYD1
Organism	Homo sapiens
Length	490 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

sleep duration · score 0.22
serum alanine aminotransferase measurement · score 0.06
aspartate aminotransferase to alanine aminotransferase ratio · score 0.06
breast cancer · score 0.06
IGF-1 measurement · score 0.05
C-reactive protein measurement · score 0.05
alkaline phosphatase measurement · score 0.04
myocardial infarction · score 0.03
colorectal cancer · score 0.03
hair color · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NB12-F1	alphafold	PREDICTED	92.99	—

Amino-acid sequence (490 residues)

MTIGRMENVE VFTAEGKGRG LKATKEFWAA DIIFAERAYS AVVFDSLVNF VCHTCFKRQE KLHRCGQCKF AHYCDRTCQK DAWLNHKNEC SAIKRYGKVP NENIRLAARI MWRVEREGTG LTEGCLVSVD DLQNHVEHFG EEEQKDLRVD VDTFLQYWPP QSQQFSMQYI SHIFGVINCN GFTLSDQRGL QAVGVGIFPN LGLVNHDCWP NCTVIFNNGN HEAVKSMFHT QMRIELRALG KISEGEELTV SYIDFLNVSE ERKRQLKKQY YFDCTCEHCQ KKLKDDLFLG VKDNPKPSQE VVKEMIQFSK DTLEKIDKAR SEGLYHEVVK LCRECLEKQE PVFADTNIYM LRMLSIVSEV LSYLQAFEEA SFYARRMVDG YMKLYHPNNA QLGMAVMRAG LTNWHAGNIE VGHGMICKAY AILLVTHGPS HPITKDLEAM RVQTEMELRM FRQNEFMYYK MREAALNNQP MQVMAEPSNE PSPALFHKKQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards