About Mixed lineage kinase domain-like protein
Mixed lineage kinase domain-like protein (MLKL) is a protein
from Homo sapiens identified by UniProt accession
Q8NB16, 471 residues long.
MolForge cross-references it against 0 known binders and
375 disease associations.
Target properties
| Protein name | Mixed lineage kinase domain-like protein |
|---|
| UniProt accession | Q8NB16 |
|---|
| Gene | MLKL |
|---|
| Organism | Homo sapiens |
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| Length | 471 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (375)
Diseases linked to this target (Open Targets).
- chronic recurrent multifocal osteomyelitis · score 0.42
- viral disease · score 0.37
- influenza · score 0.37
- MODY · score 0.34
- maturity-onset diabetes of the young · score 0.34
- adolescent idiopathic scoliosis · score 0.24
- heel bone mineral density · score 0.23
- urate measurement · score 0.23
- breast adenocarcinoma · score 0.18
- hepatocellular carcinoma · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NB16-F1 | alphafold | PREDICTED | 83.10 | — |
Amino-acid sequence (471 residues)
MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK RSVPSEKLTT AMNRFKAALE EANGEIEKFS NRSNICRFLT ASQDKILFKD VNRKLSDVWK ELSLLLQVEQ RMPVSPISQG ASWAQEDQQD ADEDRRAFQM LRRDNEKIEA SLRRLEINMK EIKETLRQYL PPKCMQEIPQ EQIKEIKKEQ LSGSPWILLR ENEVSTLYKG EYHRAPVAIK VFKKLQAGSI AIVRQTFNKE IKTMKKFESP NILRIFGICI DETVTPPQFS IVMEYCELGT LRELLDREKD LTLGKRMVLV LGAARGLYRL HHSEAPELHG KIRSSNFLVT QGYQVKLAGF ELRKTQTSMS LGTTREKTDR VKSTAYLSPQ ELEDVFYQYD VKSEIYSFGI VLWEIATGDI PFQGCNSEKI RKLVAVKRQQ EPLGEDCPSE LREIIDECRA HDPSVRPSVD EILKKLSTFS K
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