About Protein FAM184A
Protein FAM184A (FAM184A) is a protein
from Homo sapiens identified by UniProt accession
Q8NB25, 1140 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Protein FAM184A |
|---|
| UniProt accession | Q8NB25 |
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| Gene | FAM184A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1140 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- body fat percentage · score 0.31
- FEV/FVC ratio · score 0.23
- appendicular lean mass · score 0.23
- IGF-1 measurement · score 0.23
- self reported educational attainment · score 0.22
- body weight · score 0.22
- electrocardiography · score 0.21
- hip circumference · score 0.21
- body mass index · score 0.20
- adolescent idiopathic scoliosis · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NB25-F1 | alphafold | PREDICTED | 74.09 | — |
Amino-acid sequence (1140 residues)
MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ LTKVIYALNT KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE ELDLRRKIQV LESSLEDHIK MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR IVTMSREVEE IRRKFEEKLR SFGQLQVQFE KDKRLALEDL QAAHRREIQE LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE RKKLIEDYEG KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG EMALLSKHKE VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI KDLESEKSRV NERLSQLEEE RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK RTQQEYYERE LKNLQSRLEE EVTQLNEAHS KTLEELAWKH HMAIEAVHSN AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV LEDKLNTANQ EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS KLREELRLQH EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL KQNLEIQLSQ SQTSLQQLQA QFTQERQRLT QELEELEEQH QQRHKSLKEA HVLAFQTMEE EKEKEQRALE NHLQQKHSAE LQSLKDAHRE SMEGFRIEME QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH HQELAAAKME LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI MRADFNKTNE LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML TERDQIIKKL IEDNKFYQLE LVNRETNFNK VFNSSPTVGV INPLAKQKKK NDKSPTNRFV SVPNLSALES GGVGNGHPNR LDPIPNSPVH DIEFNSSKPL PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF
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