About Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (ANKRD52) is a protein
from Homo sapiens identified by UniProt accession
Q8NB46, 1076 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C |
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| UniProt accession | Q8NB46 |
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| Gene | ANKRD52 |
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| Organism | Homo sapiens |
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| Length | 1076 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- appendicular lean mass · score 0.09
- body height · score 0.08
- neoplasm · score 0.08
- microphthalmia · score 0.07
- vital capacity · score 0.06
- forced expiratory volume · score 0.06
- Isolated anophthalmia - microphthalmia · score 0.06
- Microphthalmia - ankyloblepharon - intellectual disability · score 0.05
- nanophthalmia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NB46-F1 | alphafold | PREDICTED | 85.60 | — |
Amino-acid sequence (1076 residues)
MGILSITDQP PLVQAIFSRD VEEVRSLLSQ KENINVLDQE RRTPLHAAAY VGDVPILQLL LMSGANVNAK DTLWLTPLHR AAASRNEKVL GLLLAHSADV NARDKLWQTP LHVAAANRAT KCAEALAPLL SSLNVADRSG RSALHHAVHS GHLETVNLLL NKGASLNVCD KKERQPLHWA AFLGHLEVLK LLVARGADLG CKDRKGYGLL HTAAASGQIE VVKYLLRMGA EIDEPNAFGN TALHIACYLG QDAVAIELVN AGANVNQPND KGFTPLHVAA VSTNGALCLE LLVNNGADVN YQSKEGKSPL HMAAIHGRFT RSQILIQNGS EIDCADKFGN TPLHVAARYG HELLISTLMT NGADTARRGI HDMFPLHLAV LFGFSDCCRK LLSSGQLYSI VSSLSNEHVL SAGFDINTPD NLGRTCLHAA ASGGNVECLN LLLSSGADLR RRDKFGRTPL HYAAANGSYQ CAVTLVTAGA GVNEADCKGC SPLHYAAASD TYRRAEPHTP SSHDAEEDEP LKESRRKEAF FCLEFLLDNG ADPSLRDRQG YTAVHYAAAY GNRQNLELLL EMSFNCLEDV ESTIPVSPLH LAAYNGHCEA LKTLAETLVN LDVRDHKGRT ALFLATERGS TECVEVLTAH GASALIKERK RKWTPLHAAA ASGHTDSLHL LIDSGERADI TDVMDAYGQT PLMLAIMNGH VDCVHLLLEK GSTADAADLR GRTALHRGAV TGCEDCLAAL LDHDAFVLCR DFKGRTPIHL ASACGHTAVL RTLLQAALST DPLDAGVDYS GYSPMHWASY TGHEDCLELL LEHSPFSYLE GNPFTPLHCA VINNQDSTTE MLLGALGAKI VNSRDAKGRT PLHAAAFADN VSGLRMLLQH QAEVNATDHT GRTALMTAAE NGQTAAVEFL LYRGKADLTV LDENKNTALH LACSKGHEKC ALMILAETQD LGLINATNSA LQMPLHIAAR NGLASVVQAL LSHGATVLAV DEEGHTPALA CAPNKDVADC LALILSTMKP FPPKDAVSPF SFSLLKNCSI AAAKTVGGCG ALPHGASCPY SQERPGAIGL DGCYSE
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