About Synaptotagmin-14
Synaptotagmin-14 (SYT14) is a protein
from Homo sapiens identified by UniProt accession
Q8NB59, 555 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Synaptotagmin-14 |
|---|
| UniProt accession | Q8NB59 |
|---|
| Gene | SYT14 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 555 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (122)
Diseases linked to this target (Open Targets).
- Autosomal recessive cerebellar ataxia - psychomotor retardation · score 0.46
- autosomal recessive spinocerebellar ataxia 11 · score 0.46
- vital capacity · score 0.43
- body mass index · score 0.40
- body fat percentage · score 0.39
- body weight · score 0.36
- smoking status measurement · score 0.35
- alcohol consumption measurement · score 0.34
- fat body mass · score 0.34
- lean body mass · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NB59-F1 | alphafold | PREDICTED | 65.06 | — |
Amino-acid sequence (555 residues)
MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIILML LLFLYINKKF CFENVGGFPD LGSEYSTRKN SQDKIYNSYM DKDEHGSSSE SEDEALGKYH EALSRTHNSR LPLADSRQRN YAWETRQKYS PLSAEYDGYS SEASIDEGNC IQRMRRTPPL DELQPPPYQD DSGSPHLSCT PSEIGDSKCE FSHCSNSPRC SYNKCPSEGS TGHEIESFHN KGYEEDVPSD STAVLSPEDM SAQGSSSQLP KPFDPEPEAK YGTLDVTFDY DSQEQKLLVT VTAVTDIPTY NRTGGNSWQV HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV HRMKKEKIVG EKIFYLTKLN LQGKMSLPVI LEPSYNHSGC DSQMSVSEMS CSESTSSCQS LEHGSVPEIL IGLLYNATTG RLSAEVIKGS HFKNLAANRP PNTYVKLTLL NSMGQEMSKC KTSIRRGQPN PVYKETFVFQ VALFQLSDVT LILSVYNKRS MKRKEMIGWI SLGLNSSGEE ELNHWTEMKE SKGQQVCRWH ALLES
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