tRNA-uridine aminocarboxypropyltransferase 2 (DTWD2)

About tRNA-uridine aminocarboxypropyltransferase 2

tRNA-uridine aminocarboxypropyltransferase 2 (DTWD2) is a protein from Homo sapiens identified by UniProt accession Q8NBA8, 298 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	tRNA-uridine aminocarboxypropyltransferase 2
UniProt accession	Q8NBA8
Gene	DTWD2
Organism	Homo sapiens
Length	298 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

transferrin saturation measurement · score 0.33
neuroimaging measurement · score 0.32
brain measurement · score 0.29
brain volume measurement · score 0.25
adolescent idiopathic scoliosis · score 0.16
type 2 diabetes mellitus · score 0.07
spondyloarthropathy · score 0.05
red blood cell density measurement · score 0.05
leukocyte count · score 0.03
neoplasm · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NBA8-F1	alphafold	PREDICTED	82.91	—

Amino-acid sequence (298 residues)

MESQKEARTL QEPVARPSGA SSSQTPNDKE RREGGAVPAA AALGAEADDD SADGLWELPV EPAERRPECT RCSRPQKVCL CPFLPAHPLH ISTHLYIIQH PAEENKVLRT VPLLAACLPQ DKCKVKIGRR FSEERDPELS TVCRKSGTLI LYPGAEAANL EEFILDSPVY PSTIIIIDGT WSQAKDIFYK NSLFRHPKQV QLKTSISSQY VIRMQPTNRC LSTLECAAVA LSILEKNNYI QETLLRPLQA LCSFQLQHGA QIRLSKEHLL KNGLYPKPMP KNKRKLRKME LLMNSVKI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards