About Transmembrane protein 229B
Transmembrane protein 229B (TMEM229B) is a protein
from Homo sapiens identified by UniProt accession
Q8NBD8, 167 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Transmembrane protein 229B |
|---|
| UniProt accession | Q8NBD8 |
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| Gene | TMEM229B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 167 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.50
- phosphatidylcholine measurement · score 0.46
- blood metabolite measurement · score 0.43
- glycerophospholipid measurement · score 0.43
- phosphatidylinositol measurement · score 0.40
- neurodegenerative disease · score 0.37
- Parkinson disease · score 0.36
- phosphatidylethanolamine measurement · score 0.32
- phospholipid measurement · score 0.31
- basophil percentage of leukocytes · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBD8-F1 | alphafold | PREDICTED | 89.65 | — |
Amino-acid sequence (167 residues)
MASAEPLTAL SRWYLYAIHG YFCEVMFTAA WEFVVNLNWK FPGVTSVWAL FIYGTSILIV ERMYLRLRGR CPLLLRCLIY TLWTYLWEFT TGFILRQFNA CPWDYSQFDF DFMGLITLEY AVPWFCGALI MEQFIIRNTL RLRFDKDAEP GEPSGALALA NGHVKTD
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