Kelch-like protein 23 (KLHL23)

About Kelch-like protein 23

Kelch-like protein 23 (KLHL23) is a protein from Homo sapiens identified by UniProt accession Q8NBE8, 558 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	Kelch-like protein 23
UniProt accession	Q8NBE8
Gene	KLHL23
Organism	Homo sapiens
Length	558 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
platelet count · score 0.32
serum alanine aminotransferase measurement · score 0.32
appendicular lean mass · score 0.30
platelet crit · score 0.23
body height · score 0.17
monocyte count · score 0.09
lymphocyte count · score 0.06
systolic blood pressure · score 0.03
hepatocellular carcinoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NBE8-F1	alphafold	PREDICTED	90.19	—

Amino-acid sequence (558 residues)

MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC HRAVLAACSN YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI EITKRNVQSL LEAADLLQFL SVKKACERFL VRHLDIDNCI GMHSFAEFHV CPELEKESRR ILCSKFKEVW QQEEFLEISL EKFLFILSRK NLSVWKEEAI IEPVIKWTAH DVENRIECLY NLLSYINIDI DPVYLKTALG LQRSCLLTEN KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIEALDTVW IYNSESDEWT EGLPMLNARY YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWIPIA NMIKGVGNAT ACVLHDVIYV IGGHCGYRGS CTYDKVQSYN SDINEWSLIT SSPHPEYGLC SVPFENKLYL VGGQTTITEC YDPEQNEWRE IAPMMERRME CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV GNLPSAMRSH GCVCVYNV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards