About Kyphoscoliosis peptidase
Kyphoscoliosis peptidase (KY) is a protein
from Homo sapiens identified by UniProt accession
Q8NBH2, 661 residues long.
MolForge cross-references it against 0 known binders and
209 disease associations.
Target properties
| Protein name | Kyphoscoliosis peptidase |
|---|
| UniProt accession | Q8NBH2 |
|---|
| Gene | KY |
|---|
| Organism | Homo sapiens |
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| Length | 661 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (209)
Diseases linked to this target (Open Targets).
- myofibrillar myopathy 7 · score 0.62
- body height · score 0.38
- appendicular lean mass · score 0.35
- BMI-adjusted waist circumference · score 0.34
- hereditary spastic paraplegia · score 0.33
- myotonic syndrome · score 0.24
- vital capacity · score 0.24
- sitting height measurement · score 0.24
- forced expiratory volume · score 0.24
- high density lipoprotein cholesterol measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBH2-F1 | alphafold | PREDICTED | 79.73 | — |
Amino-acid sequence (661 residues)
MELKKDINAV SIDMLLIVHS EKRRAAQGTL SDQQANPSSL LQRGGGFQGV GNGVRRWQKL EGNDFHENLV EKQHPQQPQV ITSYNSQGTQ LTVEVHPRDA MPQLLKKFSL AKRLQGDKNG NTRPRQPGGK DAHAYPWDRS SLKSMSLDLQ QFEKLDIYAS QVTAKSGLDE LVSDLLQEAH TDLERVRAIW IWICHHIEYD IAAAQEKDRQ AFKPTDILRT QKTNCDGYAG LFERMCRLAG VQCMTVPGYS KGFGYQTGQS FSGEFDHAWN AVYLEGRWHL VDSTWGSGLV DTITSKFTFL YNEFYFLTHP ALFIEDHFPD NKNWQLLKPP QSLRQFENNM YHKSEFYNKG MLSAHPETSM IRTVNGKATV TIESCAPTLF MFMLNGKQEH GLLSLRKNGM KLEVYPPTMG THKLQIFAKG NSDIYSSVLE YTLKCNYVDM GVQLPAELHQ PVGPSWFSEQ MGIMKPSHPD PIIHTSDGRC SISFSVEEGI NVLASLHGDD GPITEETQRR YIFQLHREKQ TELKVQLPHA GKFALKIFVK KRQEPGNYIF VFNYLVCCAN TKVNWPMFPE SFGNWGQDNE LLEPLSGVLP ANRNVPFKLK LHGIAKVLVK GQDTWPLTLN HEGYWEGSCS TAGCQEVYVM VLENANHNFY SYILKYKVNA Q
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