About Procollagen galactosyltransferase 1
Procollagen galactosyltransferase 1 (COLGALT1) is a protein
from Homo sapiens identified by UniProt accession
Q8NBJ5, 622 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | Procollagen galactosyltransferase 1 |
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| UniProt accession | Q8NBJ5 |
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| Gene | COLGALT1 |
|---|
| Organism | Homo sapiens |
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| Length | 622 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (77)
Diseases linked to this target (Open Targets).
- cerebral small vessel disease · score 0.70
- genetic disorder · score 0.41
- familial porencephaly · score 0.37
- myeloid white cell count · score 0.25
- breast adenocarcinoma · score 0.23
- blood protein measurement · score 0.23
- leukocyte count · score 0.23
- lymphocyte count · score 0.19
- wellbeing measurement · score 0.13
- alcohol consumption measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBJ5-F1 | alphafold | PREDICTED | 87.92 | — |
Amino-acid sequence (622 residues)
MAAAPRAGRR RGQPLLALLL LLLAPLPPGA PPGADAYFPE ERWSPESPLQ APRVLIALLA RNAAHALPTT LGALERLRHP RERTALWVAT DHNMDNTSTV LREWLVAVKS LYHSVEWRPA EEPRSYPDEE GPKHWSDSRY EHVMKLRQAA LKSARDMWAD YILFVDADNL ILNPDTLSLL IAENKTVVAP MLDSRAAYSN FWCGMTSQGY YKRTPAYIPI RKRDRRGCFA VPMVHSTFLI DLRKAASRNL AFYPPHPDYT WSFDDIIVFA FSCKQAEVQM YVCNKEEYGF LPVPLRAHST LQDEAESFMH VQLEVMVKHP PAEPSRFISA PTKTPDKMGF DEVFMINLRR RQDRRERMLR ALQAQEIECR LVEAVDGKAM NTSQVEALGI QMLPGYRDPY HGRPLTKGEL GCFLSHYNIW KEVVDRGLQK SLVFEDDLRF EIFFKRRLMN LMRDVEREGL DWDLIYVGRK RMQVEHPEKA VPRVRNLVEA DYSYWTLAYV ISLQGARKLL AAEPLSKMLP VDEFLPVMFD KHPVSEYKAH FSLRNLHAFS VEPLLIYPTH YTGDDGYVSD TETSVVWNNE HVKTDWDRAK SQKMREQQAL SREAKNSDVL QSPLDSAARD EL
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