About Formylglycine-generating enzyme
Formylglycine-generating enzyme (SUMF1) is a protein
from Homo sapiens identified by UniProt accession
Q8NBK3, 374 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | Formylglycine-generating enzyme |
|---|
| UniProt accession | Q8NBK3 |
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| Gene | SUMF1 |
|---|
| Organism | Homo sapiens |
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| Length | 374 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (116)
Diseases linked to this target (Open Targets).
- Multiple sulfatase deficiency · score 0.83
- mucosulfatidosis · score 0.81
- spinocerebellar ataxia type 15/16 · score 0.42
- mucopolysaccharidosis type 3A · score 0.27
- Multiple cutaneous leiomyomas · score 0.27
- hereditary leiomyomatosis and renal cell cancer · score 0.27
- heel bone mineral density · score 0.26
- brain measurement · score 0.24
- self reported educational attainment · score 0.24
- retinal vasculature measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBK3-F1 | alphafold | PREDICTED | 83.54 | — |
Amino-acid sequence (374 residues)
MAAPALGLVC GRCPELGLVL LLLLLSLLCG AAGSQEAGTG AGAGSLAGSC GCGTPQRPGA HGSSAAAHRY SREANAPGPV PGERQLAHSK MVPIPAGVFT MGTDDPQIKQ DGEAPARRVT IDAFYMDAYE VSNTEFEKFV NSTGYLTEAE KFGDSFVFEG MLSEQVKTNI QQAVAAAPWW LPVKGANWRH PEGPDSTILH RPDHPVLHVS WNDAVAYCTW AGKRLPTEAE WEYSCRGGLH NRLFPWGNKL QPKGQHYANI WQGEFPVTNT GEDGFQGTAP VDAFPPNGYG LYNIVGNAWE WTSDWWTVHH SVEETLNPKG PPSGKDRVKK GGSYMCHRSY CYRYRCAARS QNTPDSSASN LGFRCAADRL PTMD
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