About Transmembrane protein 178A
Transmembrane protein 178A (TMEM178A) is a protein
from Homo sapiens identified by UniProt accession
Q8NBL3, 297 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | Transmembrane protein 178A |
|---|
| UniProt accession | Q8NBL3 |
|---|
| Gene | TMEM178A |
|---|
| Organism | Homo sapiens |
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| Length | 297 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (101)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.25
- hemoglobin measurement · score 0.17
- hematocrit · score 0.17
- red blood cell density measurement · score 0.15
- Kallmann syndrome · score 0.06
- body mass index · score 0.06
- osteitis deformans · score 0.05
- grip strength measurement · score 0.05
- body weight · score 0.05
- melorheostosis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBL3-F1 | alphafold | PREDICTED | 74.39 | — |
Amino-acid sequence (297 residues)
MEPRALVTAL SLGLSLCSLG LLVTAIFTDH WYETDPRRHK ESCERSRAGA DPPDQKNRLM PLSHLPLRDS PPLGRRLLPG GPGRADPESW RSLLGLGGLD AECGRPLFAT YSGLWRKCYF LGIDRDIDTL ILKGIAQRCT AIKYHFSQPI RLRNIPFNLT KTIQQDEWHL LHLRRITAGF LGMAVAVLLC GCIVATVSFF WEESLTQHVA GLLFLMTGIF CTISLCTYAA SISYDLNRLP KLIYSLPADV EHGYSWSIFC AWCSLGFIVA AGGLCIAYPF ISRTKIAQLK SGRDSTV
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