About Transmembrane protein 87A
Transmembrane protein 87A (TMEM87A) is a protein
from Homo sapiens identified by UniProt accession
Q8NBN3, 555 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Transmembrane protein 87A |
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| UniProt accession | Q8NBN3 |
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| Gene | TMEM87A |
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| Organism | Homo sapiens |
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| Length | 555 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (19)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.20
- fibrinogen measurement · score 0.12
- hemoglobin measurement · score 0.09
- basophil count · score 0.08
- basophil percentage of leukocytes · score 0.08
- melanoma · score 0.04
- monocyte count · score 0.04
- Varicose veins · score 0.04
- granulocyte percentage of myeloid white cells · score 0.03
- monocyte percentage of leukocytes · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBN3-F1 | alphafold | PREDICTED | 71.75 | — |
Amino-acid sequence (555 residues)
MAAAAWLQVL PVILLLLGAH PSPLSFFSAG PATVAAADRS KWHIPIPSGK NYFSFGKILF RNTTIFLKFD GEPCDLSLNI TWYLKSADCY NEIYNFKAEE VELYLEKLKE KRGLSGKYQT SSKLFQNCSE LFKTQTFSGD FMHRLPLLGE KQEAKENGTN LTFIGDKTAM HEPLQTWQDA PYIFIVHIGI SSSKESSKEN SLSNLFTMTV EVKGPYEYLT LEDYPLMIFF MVMCIVYVLF GVLWLAWSAC YWRDLLRIQF WIGAVIFLGM LEKAVFYAEF QNIRYKGESV QGALILAELL SAVKRSLART LVIIVSLGYG IVKPRLGVTL HKVVVAGALY LLFSGMEGVL RVTGAQTDLA SLAFIPLAFL DTALCWWIFI SLTQTMKLLK LRRNIVKLSL YRHFTNTLIL AVAASIVFII WTTMKFRIVT CQSDWRELWV DDAIWRLLFS MILFVIMVLW RPSANNQRFA FSPLSEEEEE DEQKEPMLKE SFEGMKMRST KQEPNGNSKV NKAQEDDLKW VEENVPSSVT DVALPALLDS DEERMITHFE RSKME
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