About Tetratricopeptide repeat protein 13
Tetratricopeptide repeat protein 13 (TTC13) is a protein
from Homo sapiens identified by UniProt accession
Q8NBP0, 860 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 13 |
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| UniProt accession | Q8NBP0 |
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| Gene | TTC13 |
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| Organism | Homo sapiens |
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| Length | 860 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- body height · score 0.28
- neurodegenerative disease · score 0.27
- mean platelet volume · score 0.25
- hemoglobin measurement · score 0.22
- hematocrit · score 0.21
- red blood cell density measurement · score 0.16
- erythrocyte count · score 0.16
- platelet component distribution width · score 0.10
- nonpapillary renal cell carcinoma · score 0.07
- neoplasm · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBP0-F1 | alphafold | PREDICTED | 83.36 | — |
Amino-acid sequence (860 residues)
MAPAGCCCCC CFWGGAVAAA GAARRVLLLL LLGVLSAGLR PGALATEHYS PLSLLKQELQ HRQQQEAPAG GGGCSPQSGD WGDQYSAECG ESSFLNFHDS DCEPKGSSPC DSLLSLNTEK ILSQAKSIAE QKRFPFATDN DSTNEELAIA YVLIGSGLYD EAIRHFSTML QEEPDLVSAI YGRGIAYGKK GLHDIKNAEL ALFELSRVIT LEPDRPEVFE QRAEILSPLG RINEAVNDLT KAIQLQPSAR LYRHRGTLYF ISEDYATAHE DFQQSLELNK NQPIAMLYKG LTFFHRGLLK EAIESFKEAL KQKVDFIDAY KSLGQAYREL GNFEAATESF QKALLLNQNH VQTLQLRGMM LYHHGSLQEA LKNFKRCLQL EPYNEVCQYM KGLSHVAMGQ FYEGIKAQTK VMLNDPLPGQ KASPEYLKVK YLREYSRYLH AHLDTPLTEY NIDVDLPGSF KDHWAKNLPF LIEDYEEQPG LQPHIKDVLH QNFESYKPEV QELICVADRL GSLMQYETPG FLPNKRIHRA MGLAALEVMQ AVQRTWTNSK VRMNGKTRLM QWRDMFDIAV KWRRIADPDQ PVLWLDQMPA RSLSRGFNNH INLIRGQVIN MRYLEYFEKI LHFIKDRILV YHGANNPKGL LEVREALEKV HKVEDLLPIM KQFNTKTKDG FTVNTKVPSL KDQGKEYDGF TITITGDKVG NILFSVETQT TEERTQLYHA EIDALYKDLT AKGKVLILSS EFGEADAVCN LILSLVYYFY NLMPLSRGSS VIAYSVIVGA LMASGKEVAG KIPKGKLVDF EAMTAPGSEA FSKVAKSWMN LKSISPSYKT LPSVSETFPT LRSMIEVLNT DSSPRCLKKL
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