About Aquaporin-11
Aquaporin-11 (AQP11) is a protein
from Homo sapiens identified by UniProt accession
Q8NBQ7, 271 residues long.
MolForge cross-references it against 0 known binders and
176 disease associations.
Target properties
| Protein name | Aquaporin-11 |
|---|
| UniProt accession | Q8NBQ7 |
|---|
| Gene | AQP11 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 271 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (176)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.33
- mean platelet volume · score 0.16
- platelet component distribution width · score 0.15
- appendicular lean mass · score 0.11
- body height · score 0.10
- lean body mass · score 0.10
- nephrotic syndrome · score 0.07
- familial juvenile hyperuricemic nephropathy type 1 · score 0.06
- xanthinuria type II · score 0.06
- nephronophthisis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBQ7-F1 | alphafold | PREDICTED | 93.00 | — |
Amino-acid sequence (271 residues)
MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE FLATFQLCCC THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP CGVMMQMMLG GMSPETGAVR LLAQLVSALC SRYCTSALWS LGLTQYHVSE RSFACKNPIR VDLLKAVITE AVCSFLFHSA LLHFQEVRTK LRIHLLAALI TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW LAPSLGILLM ILMFSFFLPW LHNNHTINKK E
Explore Aquaporin-11 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets