About Solute carrier family 4 member 11
Solute carrier family 4 member 11 (SLC4A11) is a protein
from Homo sapiens identified by UniProt accession
Q8NBS3, 875 residues long.
MolForge cross-references it against 0 known binders and
195 disease associations.
Target properties
| Protein name | Solute carrier family 4 member 11 |
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| UniProt accession | Q8NBS3 |
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| Gene | SLC4A11 |
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| Organism | Homo sapiens |
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| Length | 875 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (195)
Diseases linked to this target (Open Targets).
- congenital hereditary endothelial dystrophy of cornea · score 0.85
- corneal dystrophy, Fuchs endothelial, 4 · score 0.80
- corneal dystrophy-perceptive deafness syndrome · score 0.76
- Fuchs endothelial corneal dystrophy · score 0.72
- Corneal dystrophy - perceptive deafness · score 0.69
- alkaline phosphatase measurement · score 0.26
- bone density · score 0.25
- urate measurement · score 0.25
- corneal dystrophy · score 0.20
- Abnormality of refraction · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBS3-F1 | alphafold | PREDICTED | 74.03 | — |
Amino-acid sequence (875 residues)
MAAATRRVFH LQPCENSPTM SQNGYFEDSS YYKCDTDDTF EAREEILGDE AFDTANSSIV SGESIRFFVN VNLEMQATNT ENEATSGGCV LLHTSRKYLK LKNFKEEIRA HRDLDGFLAQ ASIVLNETAT SLDNVLRTML RRFARDPDNN EPNCNLDLLM AMLFTDAGAP MRGKVHLLSD TIQGVTATVT GVRYQQSWLC IICTMKALQK RHVCISRLVR PQNWGENSCE VRFVILVLAP PKMKSTKTAM EVARTFATMF SDIAFRQKLL ETRTEEEFKE ALVHQRQLLT MVSHGPVAPR TKERSTVSLP AHRHPEPPKC KDFVPFGKGI REDIARRFPL YPLDFTDGII GKNKAVGKYI TTTLFLYFAC LLPTIAFGSL NDENTDGAID VQKTIAGQSI GGLLYALFSG QPLVILLTTA PLALYIQVIR VICDDYDLDF NSFYAWTGLW NSFFLALYAF FNLSLVMSLF KRSTEEIIAL FISITFVLDA VKGTVKIFWK YYYGHYLDDY HTKRTSSLVS LSGLGASLNA SLHTALNASF LASPTELPSA THSGQATAVL SLLIMLGTLW LGYTLYQFKK SPYLHPCVRE ILSDCALPIA VLAFSLISSH GFREIEMSKF RYNPSESPFA MAQIQSLSLR AVSGAMGLGF LLSMLFFIEQ NLVAALVNAP ENRLVKGTAY HWDLLLLAII NTGLSLFGLP WIHAAYPHSP LHVRALALVE ERVENGHIYD TIVNVKETRL TSLGASVLVG LSLLLLPVPL QWIPKPVLYG LFLYIALTSL DGNQLVQRVA LLLKEQTAYP PTHYIRRVPQ RKIHYFTGLQ VLQLLLLCAF GMSSLPYMKM IFPLIMIAMI PIRYILLPRI IEAKYLDVMD AEHRP
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