About Transmembrane protein 145
Transmembrane protein 145 (TMEM145) is a protein
from Homo sapiens identified by UniProt accession
Q8NBT3, 493 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Transmembrane protein 145 |
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| UniProt accession | Q8NBT3 |
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| Gene | TMEM145 |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (56)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- deafness · score 0.12
- hearing loss, autosomal recessive · score 0.09
- deafness, aminoglycoside-induced · score 0.07
- autosomal dominant nonsyndromic hearing loss 17 · score 0.07
- autosomal dominant nonsyndromic hearing loss 7 · score 0.07
- autosomal recessive nonsyndromic hearing loss 1B · score 0.07
- autosomal dominant nonsyndromic hearing loss · score 0.07
- appendicular lean mass · score 0.06
- otosclerosis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBT3-F1 | alphafold | PREDICTED | 78.54 | — |
Amino-acid sequence (493 residues)
MEPLRAPALR RLLPPLLLLL LSLPPRARAK YVRGNLSSKE DWVFLTRFCF LSDYGRLDFR FRYPEAKCCQ NILLYFDDPS QWPAVYKAGD KDCLAKESVI RPENNQVINL TTQYAWSGCQ VVSEEGTRYL SCSSGRSFRS GDGLQLEYEM VLTNGKSFWT RHFSADEFGI LETDVTFLLI FILIFFLSCY FGYLLKGRQL LHTTYKMFMA AAGVEVLSLL FFCIYWGQYA TDGIGNESVK ILAKLLFSSS FLIFLLMLIL LGKGFTVTRG RISHAGSVKL SVYMTLYTLT HVVLLIYEAE FFDPGQVLYT YESPAGYGLI GLQVAAYVWF CYAVLVSLRH FPEKQPFYVP FFAAYTLWFF AVPVMALIAN FGIPKWAREK IVNGIQLGIH LYAHGVFLIM TRPSAANKNF PYHVRTSQIA SAGVPGPGGS QSADKAFPQH VYGNVTFISD SVPNFTELFS IPPPATSPLP RAAPDSGLPL FRDLRPPGPL RDL
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