About Outer mitochondrial transmembrane helix translocase
Outer mitochondrial transmembrane helix translocase (ATAD1) is a protein
from Homo sapiens identified by UniProt accession
Q8NBU5, 361 residues long.
MolForge cross-references it against 0 known binders and
146 disease associations.
Target properties
| Protein name | Outer mitochondrial transmembrane helix translocase |
|---|
| UniProt accession | Q8NBU5 |
|---|
| Gene | ATAD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 361 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (146)
Diseases linked to this target (Open Targets).
- hereditary hyperekplexia · score 0.67
- neurodegenerative disease · score 0.50
- body height · score 0.27
- heel bone mineral density · score 0.26
- BMI-adjusted hip circumference · score 0.25
- bone quantitative ultrasound measurement · score 0.24
- genetic disorder · score 0.18
- waist-hip ratio · score 0.18
- erythrocyte count · score 0.18
- red blood cell density measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBU5-F1 | alphafold | PREDICTED | 84.15 | — |
Amino-acid sequence (361 residues)
MVHAEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE AQKQAEKLMK QIGVKNVKLS EYEMSIAAHL VDPLNMHVTW SDIAGLDDVI TDLKDTVILP IKKKHLFENS RLLQPPKGVL LYGPPGCGKT LIAKATAKEA GCRFINLQPS TLTDKWYGES QKLAAAVFSL AIKLQPSIIF IDEIDSFLRN RSSSDHEATA MMKAQFMSLW DGLDTDHSCQ VIVMGATNRP QDLDSAIMRR MPTRFHINQP ALKQREAILK LILKNENVDR HVDLLEVAQE TDGFSGSDLK EMCRDAALLC VREYVNSTSE ESHDEDEIRP VQQQDLHRAI EKMKKSKDAA FQNVLTHVCL D
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