Inactive phospholipid phosphatase 7 (PLPP7)

About Inactive phospholipid phosphatase 7

Inactive phospholipid phosphatase 7 (PLPP7) is a protein from Homo sapiens identified by UniProt accession Q8NBV4, 271 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.

Target properties

Protein name	Inactive phospholipid phosphatase 7
UniProt accession	Q8NBV4
Gene	PLPP7
Organism	Homo sapiens
Length	271 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (143)

Diseases linked to this target (Open Targets).

electrocardiography · score 0.33
PR interval · score 0.32
urate measurement · score 0.10
tibial muscular dystrophy · score 0.06
Congenital myasthenic syndromes · score 0.06
autosomal recessive limb-girdle muscular dystrophy type 2H · score 0.06
Distal myopathy, Nonaka type · score 0.05
GNE myopathy · score 0.05
muscular dystrophy, limb-girdle, autosomal recessive 23 · score 0.05
autosomal dominant mitochondrial myopathy with exercise intolerance · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NBV4-F1	alphafold	PREDICTED	80.03	—

Amino-acid sequence (271 residues)

MPASQSRARA RDRNNVLNRA EFLSLNQPPK GGPEPRSSGR KASGPSAQPP PAGDGARERR QSQQLPEEDC MQLNPSFKGI AFNSLLAIDI CMSKRLGVCA GRAASWASAR SMVKLIGITG HGIPWIGGTI LCLVKSSTLA GQEVLMNLLL ALLLDIMTVA GVQKLIKRRG PYETSPSLLD YLTMDIYAFP AGHASRAAMV SKFFLSHLVL AVPLRVLLVL WALCVGLSRV MIGRHHVTDV LSGFVIGYLQ FRLVELVWMP SSTCQMLISA W

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards