Synaptotagmin-8 (SYT8)

About Synaptotagmin-8

Synaptotagmin-8 (SYT8) is a protein from Homo sapiens identified by UniProt accession Q8NBV8, 387 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Synaptotagmin-8
UniProt accession	Q8NBV8
Gene	SYT8
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

prolapse of female genital organ · score 0.24
lung adenocarcinoma · score 0.18
blood protein measurement · score 0.16
pancreatic neoplasm · score 0.07
neoplasm · score 0.07
metabolite measurement · score 0.07
retinitis pigmentosa · score 0.05
optic atrophy 2 · score 0.04
retinitis pigmentosa 71 · score 0.04
Leber congenital amaurosis · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NBV8-F1	alphafold	PREDICTED	79.86	—

Amino-acid sequence (387 residues)

MGHPPVSPSA PAPAGTTAIP GLIPDLVAGT PWPRWALIAG ALAAGVLLVS CLLCAACCCC RRHRKKPRDK ESVGLGSARG TTTTHLVQPD VDGLESSPGD AQQWGCLQLS LEFDFGSQEI RVGLRQAADL RPGGTVDPYA RVSVSTQAGH RHETKVHRGT LCPVFDETCC FHIPQAELPG ATLQVQLFNF KRFSGHEPLG ELRLPLGTVD LQHVLEHWYL LGPPAATQPE QVGELCFSLR YVPSSGRLTV VVLEARGLRP GLAEPYVKVQ LMLNQRKWKK RKTATKKGTA APYFNEAFTF LVPFSQVQNV DLVLAVWDRS LPLRTEPVGK VHLGARASGQ PLQHWADMLA HARRPIAQRH PLRPAREVDR MLALQPRLRL RLPLPHS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards