UDP-glucuronic acid decarboxylase 1 (UXS1)

About UDP-glucuronic acid decarboxylase 1

UDP-glucuronic acid decarboxylase 1 (UXS1) is a protein from Homo sapiens identified by UniProt accession Q8NBZ7, 420 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.

Target properties

Protein name	UDP-glucuronic acid decarboxylase 1
UniProt accession	Q8NBZ7
Gene	UXS1
Organism	Homo sapiens
Length	420 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (113)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
blood protein measurement · score 0.26
sitting height measurement · score 0.22
appendicular lean mass · score 0.22
neurofibrillary tangles measurement · score 0.21
BMI-adjusted hip circumference · score 0.21
leukocyte count · score 0.20
body height · score 0.19
colorectal carcinoma · score 0.16
esophageal carcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NBZ7-F1	alphafold	PREDICTED	89.71	—

Amino-acid sequence (420 residues)

MVSKALLRLV SAVNRRRMKL LLGIALLAYV ASVWGNFVNM RSIQENGELK IESKIEEMVE PLREKIRDLE KSFTQKYPPV KFLSEKDRKR ILITGGAGFV GSHLTDKLMM DGHEVTVVDN FFTGRKRNVE HWIGHENFEL INHDVVEPLY IEVDQIYHLA SPASPPNYMY NPIKTLKTNT IGTLNMLGLA KRVGARLLLA STSEVYGDPE VHPQSEDYWG HVNPIGPRAC YDEGKRVAET MCYAYMKQEG VEVRVARIFN TFGPRMHMND GRVVSNFILQ ALQGEPLTVY GSGSQTRAFQ YVSDLVNGLV ALMNSNVSSP VNLGNPEEHT ILEFAQLIKN LVGSGSEIQF LSEAQDDPQK RKPDIKKAKL MLGWEPVVPL EEGLNKAIHY FRKELEYQAN NQYIPKPKPA RIKKGRTRHS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards