C-type lectin domain family 1 member A (CLEC1A)

About C-type lectin domain family 1 member A

C-type lectin domain family 1 member A (CLEC1A) is a protein from Homo sapiens identified by UniProt accession Q8NC01, 280 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	C-type lectin domain family 1 member A
UniProt accession	Q8NC01
Gene	CLEC1A
Organism	Homo sapiens
Length	280 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.25
advanced glycosylation end product-specific receptor ligand measurement · score 0.23
neoplasm · score 0.07
autoimmune disease · score 0.04
Chronic mucocutaneous candidosis · score 0.04
autosomal systemic lupus erythematosus type 16 · score 0.04
inborn error of immunity · score 0.04
pemphigus vulgaris · score 0.04
IgAD1 · score 0.04
Hashimoto's thyroiditis · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NC01-F1	alphafold	PREDICTED	84.17	—

Amino-acid sequence (280 residues)

MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTEH RAPSSTWRPV ALTLLTLCLV LLIGLAALGL LFFQYYQLSN TGQDTISQME ERLGNTSQEL QSLQVQNIKL AGSLQHVAEK LCRELYNKAG AHRCSPCTEQ WKWHGDNCYQ FYKDSKSWED CKYFCLSENS TMLKINKQED LEFAASQSYS EFFYSYWTGL LRPDSGKAWL WMDGTPFTSE LFHIIIDVTS PRSRDCVAIL NGMIFSKDCK ELKRCVCERR AGMVKPESLH VPPETLGEGD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards