Acyl-CoA-binding domain-containing protein 4 (ACBD4)

About Acyl-CoA-binding domain-containing protein 4

Acyl-CoA-binding domain-containing protein 4 (ACBD4) is a protein from Homo sapiens identified by UniProt accession Q8NC06, 268 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Acyl-CoA-binding domain-containing protein 4
UniProt accession	Q8NC06
Gene	ACBD4
Organism	Homo sapiens
Length	268 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
body height · score 0.33
systolic blood pressure · score 0.31
lean body mass · score 0.17
hypertension · score 0.17
forced expiratory volume · score 0.17
pulse pressure measurement · score 0.17
grip strength measurement · score 0.17
appendicular lean mass · score 0.14
fat body mass · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NC06-F1	alphafold	PREDICTED	64.42	—

Amino-acid sequence (268 residues)

MGTEKESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT MGPCLVPRPG FWDPIGRYKW DAWNSLGKMS REEAMSAYIT EMKLVAQKVI DTVPLGEVAE DMFGYFEPLY QVIPDMPRPP ETFLRRVTGW KEQVVNGDVG AVSEPPCLPK EPAPPSPESH SPRDLDSEVF CDSLEQLEPE LSSGQHLEES VIPGTAPCPP QRKRGCGAAR RGPRSWTCGC WGQFEHYRRA CRRCRRGCRA WRACPGPLSS LTLSVRLE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards