Reticulophagy regulator 2 (RETREG2)

About Reticulophagy regulator 2

Reticulophagy regulator 2 (RETREG2) is a protein from Homo sapiens identified by UniProt accession Q8NC44, 543 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Reticulophagy regulator 2
UniProt accession	Q8NC44
Gene	RETREG2
Organism	Homo sapiens
Length	543 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

monocyte count · score 0.23
mean corpuscular volume · score 0.22
mean reticulocyte volume · score 0.20
neutrophil count · score 0.19
platelet count · score 0.19
leukocyte count · score 0.18
mean corpuscular hemoglobin concentration · score 0.18
mean corpuscular hemoglobin · score 0.17
Red cell distribution width · score 0.16
schizophrenia · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NC44-F1	alphafold	PREDICTED	58.67	—

Amino-acid sequence (543 residues)

MASGGGGGNT GAGGGPGMGL SLGLGLGLSL GMSEATSEAE EEAATAEAVG RLATTLWLRL RGWEAVLAAA QRLLVWEKPL HSLVTAAALN GLFWLLSSSS LRPFFLLSVS LLAYFLLDLW QPRFLPDVSA SSPEEPHSDS EGAGSGARPH LLSVPELCRY LAESWLTFQI HLQELLQYKR QNPAQFCVRV CSGCAVLAVL GHYVPGIMIS YIVLLSILLW PLVVYHELIQ RMYTRLEPLL MQLDYSMKAE ANALHHKHDK RKRQGKNAPP GGDEPLAETE SESEAELAGF SPVVDVKKTA LALAITDSEL SDEEASILES GGFSVSRATT PQLTDVSEDL DQQSLPSEPE ETLSRDLGEG EEGELAPPED LLGRPQALSR QALDSEEEEE DVAAKETLLR LSSPLHFVNT HFNGAGSPPD GVKCSPGGPV ETLSPETVSG GLTALPGTLS PPLCLVGSDP APSPSILPPV PQDSPQPLPA PEEEEALTTE DFELLDQGEL EQLNAELGLE PETPPKPPDA PPLGPDIHSL VQSDQEAQAV AEP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards