Keratinocyte-associated transmembrane protein 2 (KCT2)

About Keratinocyte-associated transmembrane protein 2

Keratinocyte-associated transmembrane protein 2 (KCT2) is a protein from Homo sapiens identified by UniProt accession Q8NC54, 265 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Keratinocyte-associated transmembrane protein 2
UniProt accession	Q8NC54
Gene	KCT2
Organism	Homo sapiens
Length	265 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

cup-to-disc ratio measurement · score 0.10
drug use measurement · score 0.09
PHF-tau measurement · score 0.06
colonic neoplasm · score 0.03
anal neoplasm · score 0.03
rectal neoplasm · score 0.03
Abnormal sperm morphology · score 0.01
multiple myeloma · score 0.00
head and neck squamous cell carcinoma · score 0.00
neoplasm · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NC54-F1	alphafold	PREDICTED	57.41	—

Amino-acid sequence (265 residues)

MAAAVPKRMR GPAQAKLLPG SAIQALVGLA RPLVLALLLV SAALSSVVSR TDSPSPTVLN SHISTPNVNA LTHENQTKPS ISQISTTLPP TTSTKKSGGA SVVPHPSPTP LSQEEADNNE DPSIEEEDLL MLNSSPSTAK DTLDNGDYGE PDYDWTTGPR DDDESDDTLE ENRGYMEIEQ SVKSFKMPSS NIEEEDSHFF FHLIIFAFCI AVVYITYHNK RKIFLLVQSR KWRDGLCSKT VEYHRLDQNV NEAMPSLKIT NDYIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards