LEM domain-containing protein 2 (LEMD2)

About LEM domain-containing protein 2

LEM domain-containing protein 2 (LEMD2) is a protein from Homo sapiens identified by UniProt accession Q8NC56, 503 residues long. MolForge cross-references it against 0 known binders and 274 disease associations.

Target properties

Protein name	LEM domain-containing protein 2
UniProt accession	Q8NC56
Gene	LEMD2
Organism	Homo sapiens
Length	503 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (274)

Diseases linked to this target (Open Targets).

cataract 46 juvenile-onset · score 0.50
early-onset non-syndromic cataract · score 0.38
total early-onset cataract · score 0.37
Growth delay · score 0.27
Narrow mouth · score 0.27
Triangular face · score 0.27
Dental crowding · score 0.27
Microcephaly · score 0.27
Proptosis · score 0.27
Micrognathia · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NC56-F1	alphafold	PREDICTED	70.31	—

Amino-acid sequence (503 residues)

MAGLSDLELR RELQALGFQP GPITDTTRDV YRNKLRRLRG EARLRDEERL REEARPRGEE RLREEARLRE DAPLRARPAA ASPRAEPWLS QPASGSAYAT PGAYGDIRPS AASWVGSRGL AYPARPAQLR RRASVRGSSE EDEDARTPDR ATQGPGLAAR RWWAASPAPA RLPSSLLGPD PRPGLRATRA GPAGAARARP EVGRRLERWL SRLLLWASLG LLLVFLGILW VKMGKPSAPQ EAEDNMKLLP VDCERKTDEF CQAKQKAALL ELLHELYNFL AIQAGNFECG NPENLKSKCI PVMEAQEYIA NVTSSSSAKF EAALTWILSS NKDVGIWLKG EDQSELVTTV DKVVCLESAH PRMGVGCRLS RALLTAVTNV LIFFWCLAFL WGLLILLKYR WRKLEEEEQA MYEMVKKIID VVQDHYVDWE QDMERYPYVG ILHVRDSLIP PQSRRRMKRV WDRAVEFLAS NESRIQTESH RVAGEDMLVW RWTKPSSFSD SER

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards