About Nitric oxide-associated protein 1
Nitric oxide-associated protein 1 (NOA1) is a protein
from Homo sapiens identified by UniProt accession
Q8NC60, 698 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Nitric oxide-associated protein 1 |
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| UniProt accession | Q8NC60 |
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| Gene | NOA1 |
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| Organism | Homo sapiens |
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| Length | 698 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (57)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- risk-taking behaviour · score 0.23
- vital capacity · score 0.18
- forced expiratory volume · score 0.16
- leukocyte count · score 0.14
- bone quantitative ultrasound measurement · score 0.13
- heel bone mineral density · score 0.11
- mean platelet volume · score 0.09
- mean corpuscular volume · score 0.09
- smoking status measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NC60-F1 | alphafold | PREDICTED | 74.04 | — |
Amino-acid sequence (698 residues)
MLPARLPFRL LSLFLRGSAP TAARHGLREP LLERRCAAAS SFQHSSSLGR ELPYDPVDTE GFGEGGDMQE RFLFPEYILD PEPQPTREKQ LQELQQQQEE EERQRQQRRE ERRQQNLRAR SREHPVVGHP DPALPPSGVN CSGCGAELHC QDAGVPGYLP REKFLRTAEA DGGLARTVCQ RCWLLSHHRR ALRLQVSREQ YLELVSAALR RPGPSLVLYM VDLLDLPDAL LPDLPALVGP KQLIVLGNKV DLLPQDAPGY RQRLRERLWE DCARAGLLLA PGHQGPQRPV KDEPQDGENP NPPNWSRTVV RDVRLISAKT GYGVEELISA LQRSWRYRGD VYLVGATNAG KSTLFNTLLE SDYCTAKGSE AIDRATISPW PGTTLNLLKF PICNPTPYRM FKRHQRLKKD STQAEEDLSE QEQNQLNVLK KHGYVVGRVG RTFLYSEEQK DNIPFEFDAD SLAFDMENDP VMGTHKSTKQ VELTAQDVKD AHWFYDTPGI TKENCILNLL TEKEVNIVLP TQSIVPRTFV LKPGMVLFLG AIGRIDFLQG NQSAWFTVVA SNILPVHITS LDRADALYQK HAGHTLLQIP MGGKERMAGF PPLVAEDIML KEGLGASEAV ADIKFSSAGW VSVTPNFKDR LHLRGYTPEG TVLTVRPPLL PYIVNIKGQR IKKSVAYKTK KPPSLMYNVR KKKGKINV
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