Neuropilin and tolloid-like protein 2 (NETO2)

About Neuropilin and tolloid-like protein 2

Neuropilin and tolloid-like protein 2 (NETO2) is a protein from Homo sapiens identified by UniProt accession Q8NC67, 525 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.

Target properties

Protein name	Neuropilin and tolloid-like protein 2
UniProt accession	Q8NC67
Gene	NETO2
Organism	Homo sapiens
Length	525 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (144)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.18
Red cell distribution width · score 0.15
prostate carcinoma · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11
neoplasm · score 0.08
response to fenofibrate · score 0.08
total cholesterol change measurement · score 0.08
response to simvastatin · score 0.08
esophageal squamous cell carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NC67-F1	alphafold	PREDICTED	72.05	—

Amino-acid sequence (525 residues)

MALERLCSVL KVLLITVLVV EGIAVAQKTQ DGQNIGIKHI PATQCGIWVR TSNGGHFASP NYPDSYPPNK ECIYILEAAP RQRIELTFDE HYYIEPSFEC RFDHLEVRDG PFGFSPLIDR YCGVKSPPLI RSTGRFMWIK FSSDEELEGL GFRAKYSFIP DPDFTYLGGI LNPIPDCQFE LSGADGIVRS SQVEQEEKTK PGQAVDCIWT IKATPKAKIY LRFLDYQMEH SNECKRNFVA VYDGSSSIEN LKAKFCSTVA NDVMLKTGIG VIRMWADEGS RLSRFRMLFT SFVEPPCTSS TFFCHSNMCI NNSLVCNGVQ NCAYPWDENH CKEKKKAGVF EQITKTHGTI IGITSGIVLV LLIISILVQV KQPRKKVMAC KTAFNKTGFQ EVFDPPHYEL FSLRDKEISA DLADLSEELD NYQKMRRSST ASRCIHDHHC GSQASSVKQS RTNLSSMELP FRNDFAQPQP MKTFNSTFKK SSYTFKQGHE CPEQALEDRV MEEIPCEIYV RGREDSAQAS ISIDF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards