Adaptin ear-binding coat-associated protein 1 (NECAP1)

About Adaptin ear-binding coat-associated protein 1

Adaptin ear-binding coat-associated protein 1 (NECAP1) is a protein from Homo sapiens identified by UniProt accession Q8NC96, 275 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Adaptin ear-binding coat-associated protein 1
UniProt accession	Q8NC96
Gene	NECAP1
Organism	Homo sapiens
Length	275 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

undetermined early-onset epileptic encephalopathy · score 0.60
developmental and epileptic encephalopathy · score 0.55
lung adenocarcinoma · score 0.18
genetic disorder · score 0.18
neutrophil count · score 0.16
neutrophil percentage of leukocytes · score 0.13
Intellectual disability · score 0.11
Seizure · score 0.11
monocyte percentage of leukocytes · score 0.11
granulocyte percentage of myeloid white cells · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NC96-F1	alphafold	PREDICTED	69.58	—

Amino-acid sequence (275 residues)

MATELEYESV LCVKPDVSVY RIPPRASNRG YRASDWKLDQ PDWTGRLRIT SKGKTAYIKL EDKVSGELFA QAPVEQYPGI AVETVTDSSR YFVIRIQDGT GRSAFIGIGF TDRGDAFDFN VSLQDHFKWV KQESEISKES QEMDARPKLD LGFKEGQTIK LCIGNITNKK GGASKPRTAR GGGLSLLPPP PGGKVTIPPP SSSVAISNHV TPPPIPKSNH GGSDADILLD LDSPAPVTTP APTPVSVSND LWGDFSTASS SVPNQAPQPS NWVQF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards