About Lysosomal phospholipase A and acyltransferase
Lysosomal phospholipase A and acyltransferase (PLA2G15) is a protein
from Homo sapiens identified by UniProt accession
Q8NCC3, 412 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | Lysosomal phospholipase A and acyltransferase |
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| UniProt accession | Q8NCC3 |
|---|
| Gene | PLA2G15 |
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| Organism | Homo sapiens |
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| Length | 412 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (103)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.11
- glomerular filtration rate · score 0.09
- eosinophil count · score 0.09
- self reported educational attainment · score 0.08
- eosinophil percentage of leukocytes · score 0.07
- eosinophil percentage of granulocytes · score 0.07
- sum of eosinophil and basophil counts · score 0.06
- cognitive function measurement · score 0.06
- Familial hemophagocytic lymphohistiocytosis · score 0.05
- body mass index · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NCC3-F1 | alphafold | PREDICTED | 93.57 | — |
Amino-acid sequence (412 residues)
MGLHLRPYRV GLLPDGLLFL LLLLMLLADP ALPAGRHPPV VLVPGDLGNQ LEAKLDKPTV VHYLCSKKTE SYFTIWLNLE LLLPVIIDCW IDNIRLVYNK TSRATQFPDG VDVRVPGFGK TFSLEFLDPS KSSVGSYFHT MVESLVGWGY TRGEDVRGAP YDWRRAPNEN GPYFLALREM IEEMYQLYGG PVVLVAHSMG NMYTLYFLQR QPQAWKDKYI RAFVSLGAPW GGVAKTLRVL ASGDNNRIPV IGPLKIREQQ RSAVSTSWLL PYNYTWSPEK VFVQTPTINY TLRDYRKFFQ DIGFEDGWLM RQDTEGLVEA TMPPGVQLHC LYGTGVPTPD SFYYESFPDR DPKICFGDGD GTVNLKSALQ CQAWQSRQEH QVLLQELPGS EHIEMLANAT TLAYLKRVLL GP
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