Sugar phosphate exchanger 3 (SLC37A3)

About Sugar phosphate exchanger 3

Sugar phosphate exchanger 3 (SLC37A3) is a protein from Homo sapiens identified by UniProt accession Q8NCC5, 494 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Sugar phosphate exchanger 3
UniProt accession	Q8NCC5
Gene	SLC37A3
Organism	Homo sapiens
Length	494 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

refractive error measurement · score 0.43
retinitis pigmentosa · score 0.19
metabolite measurement · score 0.18
age at first sexual intercourse measurement · score 0.11
breast carcinoma · score 0.10
creatinine measurement · score 0.04
attention deficit hyperactivity disorder · score 0.03
antisocial behaviour measurement · score 0.03
substance abuse · score 0.03
glomerular filtration rate · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NCC5-F1	alphafold	PREDICTED	84.36	—

Amino-acid sequence (494 residues)

MAWPNVFQRG SLLSQFSHHH VVVFLLTFFS YSLLHASRKT FSNVKVSISE QWTPSAFNTS VELPVEIWSS NHLFPSAEKA TLFLGTLDTI FLFSYAVGLF ISGIVGDRLN LRWVLSFGMC SSALVVFVFG ALTEWLRFYN KWLYCCLWIV NGLLQSTGWP CVVAVMGNWF GKAGRGVVFG LWSACASVGN ILGACLASSV LQYGYEYAFL VTASVQFAGG IVIFFGLLVS PEEIGLSGIE AEENFEEDSH RPLINGGENE DEYEPNYSIQ DDSSVAQVKA ISFYQACCLP GVIPYSLAYA CLKLVNYSFF FWLPFYLSNN FGWKEAEADK LSIWYDVGGI IGGTLQGFIS DVLQKRAPVL ALSLLLAVGS LIGYSRSPND KSINALLMTV TGFFIGGPSN MISSAISADL GRQELIQRSS EALATVTGIV DGSGSIGAAV GQYLVSLIRD KLGWMWVFYF FILMTSCTIV FISPLIVREI FSLVLRRQAH ILRE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards