About Holliday junction recognition protein
Holliday junction recognition protein (HJURP) is a protein
from Homo sapiens identified by UniProt accession
Q8NCD3, 748 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Holliday junction recognition protein |
|---|
| UniProt accession | Q8NCD3 |
|---|
| Gene | HJURP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 748 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (96)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.45
- migraine disorder · score 0.23
- atopic eczema · score 0.19
- hepatocellular carcinoma · score 0.12
- metabolite measurement · score 0.12
- sitting height measurement · score 0.12
- neoplasm · score 0.11
- cancer · score 0.08
- multiple myeloma · score 0.08
- triple-negative breast cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NCD3-F1 | alphafold | PREDICTED | 45.60 | — |
Amino-acid sequence (748 residues)
MLGTLRAMEG EDVEDDQLLQ KLRASRRRFQ RRMQRLIEKY NQPFEDTPVV QMATLTYETP QGLRIWGGRL IKERNEGEIQ DSSMKPADRT DGSVQAAAWG PELPSHRTVL GADSKSGEVD ATSDQEESVA WALAPAVPQS PLKNELRRKY LTQVDILLQG AEYFECAGNR AGRDVRVTPL PSLASPAVPA PGYCSRISRK SPGDPAKPAS SPREWDPLHP SSTDMALVPR NDSLSLQETS SSSFLSSQPF EDDDICNVTI SDLYAGMLHS MSRLLSTKPS SIISTKTFIM QNWNSRRRHR YKSRMNKTYC KGARRSQRSS KENFIPCSEP VKGTGALRDC KNVLDVSCRK TGLKLEKAFL EVNRPQIHKL DPSWKERKVT PSKYSSLIYF DSSATYNLDE ENRFRTLKWL ISPVKIVSRP TIRQGHGENR QREIEIRFDQ LHREYCLSPR NQPRRMCLPD SWAMNMYRGG PASPGGLQGL ETRRLSLPSS KAKAKSLSEA FENLGKRSLE AGRCLPKSDS SSSLPKTNPT HSATRPQQTS DLHVQGNSSG IFRKSVSPSK TLSVPDKEVP GHGRNRYDEI KEEFDKLHQK YCLKSPGQMT VPLCIGVSTD KASMEVRYQT EGFLGKLNPD PHFQGFQKLP SSPLGCRKSL LGSTAIEAPS STCVARAITR DGTRDHQFPA KRPRLSEPQG SGRQGNSLGA SDGVDNTVRP GDQGSSSQPN SEERGENTSY RMEEKSDFML EKLETKSV
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