tRNA-splicing endonuclease subunit Sen2 (TSEN2)

About tRNA-splicing endonuclease subunit Sen2

tRNA-splicing endonuclease subunit Sen2 (TSEN2) is a protein from Homo sapiens identified by UniProt accession Q8NCE0, 465 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	tRNA-splicing endonuclease subunit Sen2
UniProt accession	Q8NCE0
Gene	TSEN2
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

pontocerebellar hypoplasia type 2 · score 0.72
pontocerebellar hypoplasia · score 0.60
neurodegenerative disease · score 0.50
Non-syndromic pontocerebellar hypoplasia · score 0.49
genetic disorder · score 0.41
hemolytic-uremic syndrome · score 0.33
reticulocyte count · score 0.26
erythrocyte count · score 0.25
BMI-adjusted waist-hip ratio · score 0.23
Immature Reticulocyte Fraction Measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NCE0-F1	alphafold	PREDICTED	72.06	—

Amino-acid sequence (465 residues)

MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVVNGDSGKS GGVGDPREPL GCLQEGSGCH PTTESFEKSV REDASPLPHV CCCKQDALIL QRGLHHEDGS QHIGLLHPGD RGPDHEYVLV EEAECAMSER EAAPNEELVQ RNRLICRRNP YRIFEYLQLS LEEAFFLVYA LGCLSIYYEK EPLTIVKLWK AFTVVQPTFR TTYMAYHYFR SKGWVPKVGL KYGTDLLLYR KGPPFYHASY SVIIELVDDH FEGSLRRPLS WKSLAALSRV SVNVSKELML CYLIKPSTMT DKEMESPECM KRIKVQEVIL SRWVSSRERS DQDDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards