About Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (MTMR14) is a protein
from Homo sapiens identified by UniProt accession
Q8NCE2, 650 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 |
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| UniProt accession | Q8NCE2 |
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| Gene | MTMR14 |
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| Organism | Homo sapiens |
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| Length | 650 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (88)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- Alzheimer disease · score 0.46
- Parkinson disease · score 0.46
- lysosomal storage disease · score 0.46
- multiple sclerosis · score 0.46
- autosomal dominant centronuclear myopathy · score 0.40
- centronuclear myopathy · score 0.32
- neuroinflammatory disorder · score 0.31
- breast adenocarcinoma · score 0.26
- head and neck squamous cell carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NCE2-F1 | alphafold | PREDICTED | 69.03 | — |
Amino-acid sequence (650 residues)
MAGARAAAAA ASAGSSASSG NQPPQELGLG ELLEEFSRTQ YRAKDGSGTG GSKVERIEKR CLELFGRDYC FSVIPNTNGD ICGHYPRHIV FLEYESSEKE KDTFESTVQV SKLQDLIHRS KMARCRGRFV CPVILFKGKH ICRSATLAGW GELYGRSGYN YFFSGGADDA WADVEDVTEE DCALRSGDTH LFDKVRGYDI KLLRYLSVKY ICDLMVENKK VKFGMNVTSS EKVDKAQRYA DFTLLSIPYP GCEFFKEYKD RDYMAEGLIF NWKQDYVDAP LSIPDFLTHS LNIDWSQYQC WDLVQQTQNY LKLLLSLVNS DDDSGLLVHC ISGWDRTPLF ISLLRLSLWA DGLIHTSLKP TEILYLTVAY DWFLFGHMLV DRLSKGEEIF FFCFNFLKHI TSEEFSALKT QRRKSLPARD GGFTLEDICM LRRKDRGSTT SLGSDFSLVM ESSPGATGSF TYEAVELVPA GAPTQAAWRK SHSSSPQSVL WNRPQPSEDR LPSQQGLAEA RSSSSSSSNH SDNFFRMGSS PLEVPKPRSV DHPLPGSSLS TDYGSWQMVT GCGSIQERAV LHTDSSLPFS FPDELPNSCL LAALSDRETR LQEVRSAFLA AYSSTVGLRA VAPSPSGAIG GLLEQFARGV GLRSISSNAL
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