C-type lectin domain family 18 member C (CLEC18C)

About C-type lectin domain family 18 member C

C-type lectin domain family 18 member C (CLEC18C) is a protein from Homo sapiens identified by UniProt accession Q8NCF0, 446 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	C-type lectin domain family 18 member C
UniProt accession	Q8NCF0
Gene	CLEC18C
Organism	Homo sapiens
Length	446 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

haptoglobin measurement · score 0.23
lymphocyte count · score 0.14
amino acid measurement · score 0.07
blood metabolite measurement · score 0.06
protein measurement · score 0.06
urate measurement · score 0.05
smoking status measurement · score 0.03
smoking behavior · score 0.02
body height · score 0.02
gonorrhea · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NCF0-F1	alphafold	PREDICTED	82.11	—

Amino-acid sequence (446 residues)

MLHPETSPGR GHLLAVLLAL LGTAWAEVWP PQLQEQAPMA GALNRKESFL LLSLHNRLRS WVQPPAADMR RLDWSDSLAQ LAQARAALCG IPTPSLASGL WRTLQVGWNM QLLPAGLASF VEVVSLWFAE GQRYSHAAGE CARNATCTHY TQLVWATSSQ LGCGRHLCSA GQAAIEAFVC AYSPRGNWEV NGKTIVPYKK GAWCSLCTAS VSGCFKAWDH AGGLCEVPRN PCRMSCQNHG RLNISTCHCH CPPGYTGRYC QVRCSLQCVH GRFREEECSC VCDIGYGGAQ CATKVHFPFH TCDLRIDGDC FMVSSEADTY YRARMKCQRK GGVLAQIKSQ KVQDILAFYL GRLETTNEVI DSDFETRNFW IGLTYKTAKD SFRWATGEHQ AFTSFAFGQP DNHGFGNCVE LQASAAFNWN NQRCKTRNRY ICQFAQEHIS RWGPGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards