NFATC2-interacting protein (NFATC2IP)

About NFATC2-interacting protein

NFATC2-interacting protein (NFATC2IP) is a protein from Homo sapiens identified by UniProt accession Q8NCF5, 419 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	NFATC2-interacting protein
UniProt accession	Q8NCF5
Gene	NFATC2IP
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

serum non-albumin protein measurement · score 0.14
lymphocyte count · score 0.14
hemoglobin measurement · score 0.10
electrocardiography · score 0.09
total blood protein measurement · score 0.07
risk-taking behaviour · score 0.06
isolated agammaglobulinemia · score 0.05
severe combined immunodeficiency due to CTPS1 deficiency · score 0.05
T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.05
severe combined immunodeficiency due to CARD11 deficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NCF5-F1	alphafold	PREDICTED	65.18	—

Amino-acid sequence (419 residues)

MAEPVGKRGR WSGGSGAGRG GRGGWGGRGR RPRAQRSPSR GTLDVVSVDL VTDSDEEILE VATARGAADE VEVEPPEPPG PVASRDNSNS DSEGEDRRPA GPPREPVRRR RRLVLDPGEA PLVPVYSGKV KSSLRLIPDD LSLLKLYPPG DEEEAELADS SGLYHEGSPS PGSPWKTKLR TKDKEEKKKT EFLDLDNSPL SPPSPRTKSR THTRALKKLS EVNKRLQDLR SCLSPKPPQG QEQQGQEDEV VLVEGPTLPE TPRLFPLKIR CRADLVRLPL RMSEPLQSVV DHMATHLGVS PSRILLLFGE TELSPTATPR TLKLGVADII DCVVLTSSPE ATETSQQLQL RVQGKEKHQT LEVSLSRDSP LKTLMSHYEE AMGLSGRKLS FFFDGTKLSG RELPADLGME SGDLIEVWG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards