About Polypeptide N-acetylgalactosaminyltransferase 6
Polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6) is a protein
from Homo sapiens identified by UniProt accession
Q8NCL4, 622 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Polypeptide N-acetylgalactosaminyltransferase 6 |
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| UniProt accession | Q8NCL4 |
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| Gene | GALNT6 |
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| Organism | Homo sapiens |
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| Length | 622 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (87)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.38
- refractive error measurement · score 0.37
- Red cell distribution width · score 0.34
- lymphocyte count · score 0.25
- blood protein measurement · score 0.24
- keratoconus · score 0.24
- total cholesterol measurement · score 0.24
- serum gamma-glutamyl transferase measurement · score 0.20
- Hypercholesterolemia · score 0.15
- alkaline phosphatase measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NCL4-F1 | alphafold | PREDICTED | 88.72 | — |
Amino-acid sequence (622 residues)
MRLLRRRHMP LRLAMVGCAF VLFLFLLHRD VSSREEATEK PWLKSLVSRK DHVLDLMLEA MNNLRDSMPK LQIRAPEAQQ TLFSINQSCL PGFYTPAELK PFWERPPQDP NAPGADGKAF QKSKWTPLET QEKEEGYKKH CFNAFASDRI SLQRSLGPDT RPPECVDQKF RRCPPLATTS VIIVFHNEAW STLLRTVYSV LHTTPAILLK EIILVDDAST EEHLKEKLEQ YVKQLQVVRV VRQEERKGLI TARLLGASVA QAEVLTFLDA HCECFHGWLE PLLARIAEDK TVVVSPDIVT IDLNTFEFAK PVQRGRVHSR GNFDWSLTFG WETLPPHEKQ RRKDETYPIK SPTFAGGLFS ISKSYFEHIG TYDNQMEIWG GENVEMSFRV WQCGGQLEII PCSVVGHVFR TKSPHTFPKG TSVIARNQVR LAEVWMDSYK KIFYRRNLQA AKMAQEKSFG DISERLQLRE QLHCHNFSWY LHNVYPEMFV PDLTPTFYGA IKNLGTNQCL DVGENNRGGK PLIMYSCHGL GGNQYFEYTT QRDLRHNIAK QLCLHVSKGA LGLGSCHFTG KNSQVPKDEE WELAQDQLIR NSGSGTCLTS QDKKPAMAPC NPSDPHQLWL FV
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