About Transmembrane protein 116
Transmembrane protein 116 (TMEM116) is a protein
from Homo sapiens identified by UniProt accession
Q8NCL8, 245 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Transmembrane protein 116 |
|---|
| UniProt accession | Q8NCL8 |
|---|
| Gene | TMEM116 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 245 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (121)
Diseases linked to this target (Open Targets).
- platelet count · score 0.38
- reticulocyte count · score 0.35
- platelet crit · score 0.21
- Red cell distribution width · score 0.20
- hair color · score 0.12
- lymphocyte count · score 0.12
- eosinophil count · score 0.11
- Immature Reticulocyte Fraction Measurement · score 0.11
- angina pectoris · score 0.11
- mean corpuscular hemoglobin concentration · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NCL8-F1 | alphafold | PREDICTED | 73.64 | — |
Amino-acid sequence (245 residues)
MKHTQSGQST SPLVIDYTCR VCQMAFVFSS LIPLLLMTPV FCLGNTSECF QNFSQSHKCI LMHSPPSAMA ELPPSANTSV CSTLYFYGIA IFLGSFVLSL LTIMVLLIRA QTLYKKFVKS TGFLGSEQWA VIHIVDQRVR FYPVAFFCCW GPAVILMIIK LTKPQDTKLH MALYVLQALT ATSQGLLNCG VYGWTQHKFH QLKQEARRDA DTQTPLLCSQ KRFYSRGLNS LESTLTFPAS TSTIF
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