About Arrestin domain-containing protein 4
Arrestin domain-containing protein 4 (ARRDC4) is a protein
from Homo sapiens identified by UniProt accession
Q8NCT1, 418 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | Arrestin domain-containing protein 4 |
|---|
| UniProt accession | Q8NCT1 |
|---|
| Gene | ARRDC4 |
|---|
| Organism | Homo sapiens |
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| Length | 418 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (83)
Diseases linked to this target (Open Targets).
- cortical thickness · score 0.34
- cortical surface area measurement · score 0.34
- body height · score 0.33
- IGF-1 measurement · score 0.33
- brain measurement · score 0.32
- neuroimaging measurement · score 0.27
- drug use measurement · score 0.27
- body mass index · score 0.23
- BMI-adjusted waist-hip ratio · score 0.21
- creatinine measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NCT1-F1 | alphafold | PREDICTED | 79.88 | — |
Amino-acid sequence (418 residues)
MGGEAGCAAA VGAEGRVKSL GLVFEDERKG CYSSGETVAG HVLLEASEPV ALRALRLEAQ GRATAAWGPS TCPRASASTA ALAVFSEVEY LNVRLSLREP PAGEGIILLQ PGKHEFPFRF QLPSEPLVTS FTGKYGSIQY CVRAVLERPK VPDQSVKREL QVVSHVDVNT PALLTPVLKT QEKMVGCWFF TSGPVSLSAK IERKGYCNGE AIPIYAEIEN CSSRLIVPKA AIFQTQTYLA SGKTKTIRHM VANVRGNHIA SGSTDTWNGK TLKIPPVTPS ILDCCIIRVD YSLAVYIHIP GAKKLMLELP LVIGTIPYNG FGSRNSSIAS QFSMDMSWLT LTLPEQPEAP PNYADVVSEE EFSRHIPPYP QPPNCEGEVC CPVFACIQEF RFQPPPLYSE VDPHPSDVEE SQPVSFIL
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