About Basal body-orientation factor 1
Basal body-orientation factor 1 (BBOF1) is a protein
from Homo sapiens identified by UniProt accession
Q8ND07, 529 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | Basal body-orientation factor 1 |
|---|
| UniProt accession | Q8ND07 |
|---|
| Gene | BBOF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 529 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (134)
Diseases linked to this target (Open Targets).
- methylmalonate semialdehyde dehydrogenase deficiency · score 0.46
- Red cell distribution width · score 0.30
- erythrocyte count · score 0.22
- blood protein measurement · score 0.22
- mean corpuscular hemoglobin concentration · score 0.22
- mean corpuscular hemoglobin · score 0.17
- genetic disorder · score 0.16
- red blood cell density measurement · score 0.15
- mean corpuscular volume · score 0.15
- ganglion cell inner plexiform layer thickness measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8ND07-F1 | alphafold | PREDICTED | 80.70 | — |
Amino-acid sequence (529 residues)
MPSKGKDKKK GKSKGKDTKK LIKTDESVVD RAKANASLWE ARLEVTELSR IKYRDTSRIL AKSNEDLKKK QCKMEKDIMS VLSYLKKQDQ EKDNMIEKLK QQLNETKEKA QEEKDKLEQK YTRQINELEG QFHQKAKEIG MIHTELKAVR QFQKRKIQVE RELDDLKENL RNTERIHQET LRRLESRFFE EKHRLEQEAE KKIIMLAERA HHEAIVQLND AGRNVFKEND YLQKALAYHL KETDALQKNS QKLQESHTLL LHQKEINDLL VKEKIMQLVQ QRSQIQTLQK KVVNLETALS YMTKEFESEV LKLQQHAMIE NQAGQVEIDK LQHLLQMKDR EMNRVKKLAK NILDERTEVE RFFLDALHQV KQQILISRKH YKQIAQAAFN LKMRAACTGR TEYPKIRTFD GREHSTNSVN QDLLEAEKWT HIEGNVDIGD LTWEQKEKVL RLLFAKMNGC PSRKYNQSSR PPVPDYVVSD SGETKEFGDE SKLQDKIFIT QQIAISDSSG EVVLPTIPKE PQESDTGTF
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