About E3 ubiquitin-protein ligase ZNRF1
E3 ubiquitin-protein ligase ZNRF1 (ZNRF1) is a protein
from Homo sapiens identified by UniProt accession
Q8ND25, 227 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase ZNRF1 |
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| UniProt accession | Q8ND25 |
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| Gene | ZNRF1 |
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| Organism | Homo sapiens |
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| Length | 227 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (36)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.16
- ulcerative colitis · score 0.08
- vital capacity · score 0.05
- adolescent idiopathic scoliosis · score 0.04
- head and neck squamous cell carcinoma · score 0.04
- BMI-adjusted waist circumference · score 0.04
- high density lipoprotein cholesterol measurement · score 0.03
- ovarian carcinoma · score 0.02
- acute lymphoblastic leukemia · score 0.02
- diabetic retinopathy · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8ND25-F1 | alphafold | PREDICTED | 66.99 | — |
Amino-acid sequence (227 residues)
MGGKQSTAAR SRGPFPGVST DDSAVPPPGG APHFGHYRTG GGAMGLRSRS VSSVAGMGMD PSTAGGVPFG LYTPASRGTG DSERAPGGGG SASDSTYAHG NGYQETGGGH HRDGMLYLGS RASLADALPL HIAPRWFSSH SGFKCPICSK SVASDEMEMH FIMCLSKPRL SYNDDVLTKD AGECVICLEE LLQGDTIARL PCLCIYHKSC IDSWFEVNRS CPEHPAD
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