About Liprin-beta-2
Liprin-beta-2 (PPFIBP2) is a protein
from Homo sapiens identified by UniProt accession
Q8ND30, 876 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Liprin-beta-2 |
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| UniProt accession | Q8ND30 |
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| Gene | PPFIBP2 |
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| Organism | Homo sapiens |
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| Length | 876 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- hair color · score 0.45
- prostate carcinoma · score 0.43
- hair colour measurement · score 0.39
- cutaneous melanoma · score 0.27
- metabolite measurement · score 0.07
- phospholipid measurement · score 0.03
- blood protein measurement · score 0.03
- mean corpuscular volume · score 0.03
- interstitial lung disease · score 0.02
- Rheumatoid arthritis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8ND30-F1 | alphafold | PREDICTED | 70.08 | — |
Amino-acid sequence (876 residues)
MASDASHALE AALEQMDGII AGTKTGADLS DGTCEPGLAS PASYMNPFPV LHLIEDLRLA LEMLELPQER AALLSQIPGP TAAYIKEWFE ESLSQVNHHS AASNETYQER LARLEGDKES LILQVSVLTD QVEAQGEKIR DLEVCLEGHQ VKLNAAEEML QQELLSRTSL ETQKLDLMTE VSELKLKLVG MEKEQREQEE KQRKAEELLQ ELRHLKIKVE ELENERNQYE WKLKATKAEV AQLQEQVALK DAEIERLHSQ LSRTAALHSE SHTERDQEIQ RLKMGMETLL LANEDKDRRI EELTGLLNQY RKVKEIVMVT QGPSERTLSI NEEEPEGGFS KWNATNKDPE ELFKQEMPPR CSSPTVGPPP LPQKSLETRA QKKLSCSLED LRSESVDKCM DGNQPFPVLE PKDSPFLAEH KYPTLPGKLS GATPNGEAAK SPPTICQPDA TGSSLLRLRD TESGWDDTAV VNDLSSTSSG TESGPQSPLT PDGKRNPKGI KKFWGKIRRT QSGNFYTDTL GMAEFRRGGL RATAGPRLSR TRDSKGQKSD ANAPFAQWST ERVCAWLEDF GLAQYVIFAR QWVSSGHTLL TATPQDMEKE LGIKHPLHRK KLVLAVKAIN TKQEEKSALL DHIWVTRWLD DIGLPQYKDQ FHESRVDRRM LQYLTVNDLL FLKVTSQLHH LSIKCAIHVL HVNKFNPHCL HRRPADESNL SPSEVVQWSN HRVMEWLRSV DLAEYAPNLR GSGVHGGLII LEPRFTGDTL AMLLNIPPQK TLLRRHLTTK FNALIGPEAE QEKREKMASP AYTPLTTTAK VRPRKLGFSH FGNIRKKKFD ESTDYICPME PSDGVSDSHR VYSGYRGLSP LDAPELDGLD QVGQIS
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