About Maestro heat-like repeat-containing protein family member 1
Maestro heat-like repeat-containing protein family member 1 (MROH1) is a protein
from Homo sapiens identified by UniProt accession
Q8NDA8, 1641 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | Maestro heat-like repeat-containing protein family member 1 |
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| UniProt accession | Q8NDA8 |
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| Gene | MROH1 |
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| Organism | Homo sapiens |
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| Length | 1641 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (17)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist circumference · score 0.26
- body height · score 0.26
- blood protein measurement · score 0.21
- serum metabolite measurement · score 0.21
- type 2 diabetes mellitus · score 0.09
- complication · score 0.05
- eosinophil count · score 0.03
- mean corpuscular volume · score 0.02
- HMG CoA reductase inhibitor use measurement · score 0.02
- mean corpuscular hemoglobin · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NDA8-F1 | alphafold | PREDICTED | 84.16 | — |
Amino-acid sequence (1641 residues)
MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL LAFLLPRLDT SNERTRVGTL QVVRHVINSA AAQMEDKKPF ILSSMRLPLL DTNSKVKRAV VQVISAMAHH GYLEQPGGEA MIEYIVQQCA LPPEQEPEKP GPGSKDPKAD SVRAISVRTL YLVSTTVDRM SHVLWPYLLQ FLTPVRFTGA LTPLCRSLVH LAQKRQEAGA DAFLIQYDAH ASLPSPYAVT GRLLVVSSSP YLGDGRGAAA LRLLSVLHPN IHPLLGQHWE TTVPLLLGYL DEHTEETLPQ EEWEEKLLMF LRDTLAIISD NAWICQLSLE LCRQLPCYDE APQEKNFLYK CIGTTLGAAS SKEVVRKHLQ ELLETARYQE EAEREGLACC FGICAISHLE DTLAQLEDFV RSEVFRKSIG ILNIFKDRSE NEVEKVKSAL ILCYGHVAAR APRELVLAKV ESDILRNICQ HFSTKVLGIK VETKDPALKL CLVQSVCMVS RAICSSTQAG SFHFTRKAEL VAQMMEFIRA EPPDSLRTPI RKKAMLTCTY LVSVEPALDE QARADVIHGC LHSIMALLPE PKEEDGGCQK SLYLETLHAL EDLLTSLLQR NMTPQGLQIM IEHLSPWIKS PRGHERARAL GLSALLLRYF LEHLRVSALV PFHNLGLLIG LFSPRCADLW PATRQEAVDC VYSLLYLQLG YEGFSRDYRD DVAERLLSLK DGLVHPDPAI LFHTCHSVGQ IIAKRLPPDQ LISLLLTMFE ALGDPEKNCS RAATVMINCL LQERGGVLQE KVPEIVSVLR SKLQEAQGEH VLPAAQHSVY LLATQHCAAV VSSLLGSPLP LDSHTCMLWR ALAVEPRLAA QVLGLLLEKM SRDVPFKESR AFLLGRTPDR VATLLPLSAT CALFEVMSTP AAGPAVLELY PQLFVVLLLR VSCTVGVQLP RNLQAQERRG ASPALATRNL EPCSSAVDTL RSMLLRSGSE DVVQRMDLEG GWELLRTSAG HEEGATRLAR AMAEHAGPRL PLVLKTLACT HSSAYENQRV TTTAFLAELL NSNVANDLML LDSLLESLAA RQKDTCASVR RLVLRGLANL ASGCPDKVRT HGPQLLTAMI GGLDDGDNPH SPVALEAMLG LARLVHLVES WDLRSGLLHV AIRIRPFFDS EKMEFRTASI RLFGHLNKVC HGDCEDVFLD QVVGGLAPLL LHLQDPQATV ASACRFALRM CGPNLACEEL SAAFQKHLQE GRALHFGEFL NTTCKHLMHH FPDLLGRLLT TCLFYFKSSW ENVRAAAPLF TGFLVLHSEP RQQPQVDLDQ LIAALQILLK DPAPEVRTRA AEALGRLVKL A
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