B-cell scaffold protein with ankyrin repeats (BANK1)

About B-cell scaffold protein with ankyrin repeats

B-cell scaffold protein with ankyrin repeats (BANK1) is a protein from Homo sapiens identified by UniProt accession Q8NDB2, 785 residues long. MolForge cross-references it against 0 known binders and 240 disease associations.

Target properties

Protein name	B-cell scaffold protein with ankyrin repeats
UniProt accession	Q8NDB2
Gene	BANK1
Organism	Homo sapiens
Length	785 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (240)

Diseases linked to this target (Open Targets).

systemic lupus erythematosus · score 0.54
mean platelet volume · score 0.48
lean body mass · score 0.45
body mass index · score 0.42
body weight · score 0.40
Crohn's disease · score 0.38
high density lipoprotein cholesterol measurement · score 0.36
brain volume measurement · score 0.36
gut microbiome measurement · score 0.35
fat body mass · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NDB2-F1	alphafold	PREDICTED	60.82	—

Amino-acid sequence (785 residues)

MLPAAPGKGL GSPDPAPCGP APPGNTKDII MIYEEDAEEW ALYLTEVFLH VVKREAILLY RLENFSFRHL ELLNLTSYKC KLLILSNSLL RDLTPKKCQF LEKILHSPKS VVTLLCGVKS SDQLYELLNI SQSRWEISTE QEPEDYISVI QSIIFKDSED YFEVNIPTDL RAKHSGEISE RKEIEELSEA SRNTIPLAVV LPTEIPCENP GEIFIILRDE VIGDTVEVEF TSSNKRIRTR PALWNKKVWC MKALEFPAGS VHVNVYCDGI VKATTKIKYY PTAKAKECLF RMADSGESLC QNSIEELDGV LTSIFKHEIP YYEFQSLQTE ICSQNKYTHF KELPTLLHCA AKFGLKNLAI HLLQCSGATW ASKMKNMEGS DPAHIAERHG HKELKKIFED FSIQEIDINN EQENDYEEDI ASFSTYIPST QNPAFHHESR KTYGQSADGA EANEMEGEGK QNGSGMETKH SPLEVGSESS EDQYDDLYVF IPGADPENNS QEPLMSSRPP LPPPRPVANA FQLERPHFTL PGTMVEGQME RSQNWGHPGV RQETGDEPKG EKEKKEEEKE QEEEEDPYTF AEIDDSEYDM ILANLSIKKK TGSRSFIINR PPAPTPRPTS IPPKEETTPY IAQVFQQKTA RRQSDDDKFC GLPKKQDRAR IESPAFSTLR GCLTDGQEEL ILLQEKVKNG KMSMDEALEK FKHWQMGKSG LEMIQQEKLR QLRDCIIGKR PEEENVYNKL TIVHHPGGKE TAHNENKFYN VHFSNKLPAR PQVEKEFGFC CKKDH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards