About MAPK-interacting and spindle-stabilizing protein-like
MAPK-interacting and spindle-stabilizing protein-like (MAPK1IP1L) is a protein
from Homo sapiens identified by UniProt accession
Q8NDC0, 245 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | MAPK-interacting and spindle-stabilizing protein-like |
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| UniProt accession | Q8NDC0 |
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| Gene | MAPK1IP1L |
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| Organism | Homo sapiens |
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| Length | 245 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- schizophrenia · score 0.24
- self reported educational attainment · score 0.24
- intelligence · score 0.24
- Knee pain · score 0.23
- chronotype measurement · score 0.12
- urate measurement · score 0.09
- Red cell distribution width · score 0.06
- leukocyte count · score 0.05
- blood protein measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NDC0-F1 | alphafold | PREDICTED | 51.85 | — |
Amino-acid sequence (245 residues)
MSDEFSLADA LPEHSPAKTS AVSNTKPGQP PQGWPGSNPW NNPSAPSSVP SGLPPSATPS TVPFGPAPTG MYPSVPPTGP PPGPPAPFPP SGPSCPPPGG PYPAPTVPGP GPTGPYPTPN MPFPELPRPY GAPTDPAAAG PLGPWGSMSS GPWAPGMGGQ YPTPNMPYPS PGPYPAPPPP QAPGAAPPVP WGTVPPGAWG PPAPYPAPTG SYPTPGLYPT PSNPFQVPSG PSGAPPMPGG PHSYH
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